Dr. Grace Ann Spatafora
Professor of Biology, Middlebury College
276 Bicentennial Way, MBH354
Middlebury, Vermont 05753
B.S. Duke University, Durham, North Carolina Psychology 76-80
M.S. University of Richmond, Richmond, Virginia Biology '80-'83
Ph.D. St. Louis University, St. Louis, Missouri Biology '83-'88
Post-doc Washington University, St. Louis, Missouri Biology '88-'91
Post-doc University of Alabama, Birmingham, Alabama Microbiology '91-'92
1988-1991: NRSA Post Doctoral Fellow, Washington University, Dept. of Biology, St. Louis, MO.
1992-1995: Visiting Assistant Professor, Department of Biology, Middlebury College, VT.
1995-1999: Assistant Professor, Department of Biology, Middlebury College, VT.
1999-2004: Associate Professor, Department of Biology, Middlebury College, VT.
2004-present: Professor, Department of Biology, Middlebury College, VT.
2004-2007: Chair, Department of Biology, Middlebury College, VT.
2007-2010: Promotions Committee, Middlebury College, VT
2012-2014: Chair, Department of Biology, Middlebury College, VT
American Society for Microbiology
International Association for Dental Research
Sigma Xi Scientific Research Society
Vermont Academy of Science and Engineering
1999: Perkins Award for Excellence in Teaching nominee, Middlebury College, VT.
2002-2006: Oral, Dental and Craniofacial Sciences (ODCS), Center for Scientific Review, NIH
2007-2011: American Society for Microbiology Carski Award nominee
2009: Inducted into the Vermont Academy of Science and Engineering
2009–present: Distinguished Professor, Irene Heinz and John LaPorte Given Professor in the Premedical Sciences (Endowed Chair)
2010-present: Vermont Academy of Science and Engineering, Education Outreach Coordinator and STEM
2013-present: President, Microbiology/Immunology Subgroup, International Association for Dental Research
2013: Gladstone Award Honoring Excellence in Teaching (nominee)
2014: Council for Undergraduate Research, Biology Mentor Award: Honorable Mention
NIH/NIDCR 1R01DE014711 1R01 DE014711 7/1/10 – 6/30/15
Investigating SloR virulence gene metalloregulation in the oral pathogen, Streptococcus mutans. The major goal of this research project is to reveal the molecular and biochemical details of the SloR-SRE binding interaction so that it may be targeted for the development of an anti-caries therapeutic.
1. Merchant, A.T.*, and G. Spatafora. 2014. A role for the DtxR family of metalloregulators in gram positive pathogenesis. Mol. Oral Microbiol. 29:1-10. Invited Review (F1000Prime recommended).
2. Haswell, J.R.*, B.W. Pruitt*, L.P. Cornacchione*, C.L. Coe*, E.G. Smith* and G. Spatafora. 2013. Characterization of the functioinal domains of the SloR metalloregulatory protein in Streptococcus mutans. J. Bacteriol. 195:126-134
3. Smith, E.G.* and G. Spatafora. 2011. Gene Regulation in Streptococcus mutans: Complex Control in a Complex Environment. J. Dent. Res. (featured as a Critical Review in Oral Biology and Medicine) 91(2):133-141.
4. O’Rourke, K.P.*, J.D. Shaw*, M.W. Pesesky*, B.T. Cook*. S.M. Roberts*, J. P. Bond and G. Spatafora. 2010. Genome-wide characterization of the SloR metalloregulome in Streptococcus mutans. J. Bacteriol. 192:1433-1443.
5. Levine, R.B.*, M.S. Constanza-Robinson and G. Spatafora. 2010. Neochloris oleoabundansgrown on anaerobically digested dairy manure for concomitant nutrient removal and biodiesel feedstock production. Biomass and Bioenergy, 35:40-49
6. Dunning, D.W.*, L.W. McCall*, W.F. Powell*, W. T. Arscott*, E. M. McConocha*, S. D. Goodman, and G. Spatafora. 2008. SloR modulatioin of the Streptococcus mutans acid tolerance response involves the GcrR response regulator as an essential intermediary. Microbiology154:1132-43.
7. Rolerson, E*, A. Swick*, L. Newlon*, C. Palmer*, Y. Pan*, B. Keeshan*, and G. Spatafora. 2006. The SloR/Dlg metalloregulator modulates Streptococcus mutans virulence gene expression. J. Bacteriol. 188:5033-5044.